I've had some luck advancing Technobabe in City of Heroes. A few months ago I picked up the Atomic Blast power from Radiation Blast. I wasn't impressed with it. The endurance drain and reduced endurance recovery made it less than useful for me. Many times minions would still be standing after the blast, admittedly in rough shape, but it didn't seem like a great power for a Defender.
Now it is one of my favorite attack powers. I just learned how to make up for the endurance drain with the use of inspirations and then activating Accelerate Metabolism or Power Sink to recover additional endurance. I can be back on the attack (or healing myself and teammates) before survivors of the Atomic Blast can recover. I had a friend a couple weeks ago notice how using Atomic Blast didn't seem to phase me.
Now as an added bonus I have the Burnout power from the Speed group. When activated this power recharges all the powers in my primary and secondary power sets.... including Atomic Blast.
I can now set off two Atomic Blasts in short order with minimal drawbacks to myself except using about a third of my inspirations and having a couple toggle powers turn off on me. Few things can survive the dual blasts.
It's gotten to the point now where I use a handful of defensive inspirations to buy me the time to draw multiple mobs together to really nuke the heck out of them all. Technobabe is turning into a real combat character; I have no trouble soloing with her like I did back in the day.
I'm just glad I stuck with Atomic Blast. As I've mentioned it did not impress me much when I first used it, but now it is awesome. I've got it slotted for six enhancements and in a few more levels I'll be ready to find just the right set of invention enhancements to make it even more deadly.
If you play City of Heroes I hope this helps you out some. Are there any other tricks anyone has picked up using this power?